The pituitary gland is a small gland that sits in the sella turcica, a saddle-shaped depression located in the bone at the base of the skull. It produces hormones that control different processes in the body, including metabolism, growth and reproduction. “Empty sella” is a radiologic description and not a clinical condition - the sella turcica is either partially filled with cerebrospinal fluid and a very small pituitary gland (partially empty sella), or completely filled with cerebrospinal fluid with no visualized pituitary gland (completely empty sella). Empty sella syndrome may occur as a primary disorder, from an unknown cause, or as a secondary disorder, from an underlying condition such as a treated pituitary tumor, head trauma, or elevated intracranial pressure. In empty sella syndrome, the pituitary gland is usually functioning normally. In empty sella syndrome, the pituitary gland is usually functioning normally, so most individuals do not have any symptoms.