May 8, 2025
Read
May 8, 2025

Recognizing the Symptoms of Terminal Brain Cancer

Recognizing the Symptoms of Terminal Brain Cancer

Contents

Table of contents placeholder

A terminal brain cancer diagnosis represents a profoundly serious and advanced stage of the disease. This condition often involves high-grade malignant tumors, such as glioblastoma multiforme (GBM), which accounts for 47.7 percent of all malignant brain and other central nervous system tumors. The seriousness of terminal brain cancer lies in its rapid progression and the profound impact it has on patients' physical, cognitive, and emotional well-being.

The purpose of this article is to provide information on the symptoms associated with terminal brain cancer. By understanding these symptoms, patients and caregivers can better manage the disease, seek appropriate palliative care, and improve the quality of life during this challenging time.

Understanding the Symptoms of Terminal Brain Cancer

Overview of Terminal Brain Cancer

Terminal brain cancer refers to an advanced stage of cancer where the brain tumor is no longer responsive to treatment. This typically occurs with high-grade malignant tumors like glioblastoma multiforme (GBM), which is one of the most aggressive forms of brain cancer.

Several factors contribute to a patient being given a terminal diagnosis:

  • Tumor location: Tumors in critical areas of the brain that control vital functions are often inoperable.
  • Tumor size and spread: Large tumors, or those that have spread extensively throughout the brain, are more difficult to treat.
  • Tumor grade: Higher-grade tumors (grades 3 and 4) grow more quickly and are more resistant to treatment
  • Treatment response: If the tumor continues to grow despite aggressive treatment, it may be deemed terminal.

Symptom awareness is crucial for maintaining quality of life in terminal brain cancer patients. Common symptoms include persistent headaches, seizures, cognitive changes, personality alterations, and physical impairments. Recognizing and managing these symptoms can help improve patient comfort and allow for better palliative care. Additionally, understanding the progression of symptoms can help patients and caregivers prepare for end-of-life care and make informed decisions about treatment options.

Common Physical Symptoms

Headaches

Headaches in terminal brain cancer are often severe, persistent, and worsen over time. Up to 36 percent of brain tumor patients experience headaches in their last weeks of life. Headaches typically occur due to increased intracranial pressure caused by tumor growth, swelling, or cerebrospinal fluid blockage. They may not respond well to over-the-counter pain medications and can be accompanied by nausea, vomiting, and visual disturbances. The pain may be localized or generalized, depending on the tumor location, and can significantly impact the patient’s quality of life.

Seizures

Seizures are a common symptom of terminal brain cancer, affecting about half of all patients. They can vary in type and intensity, ranging from focal seizures (affecting a specific part of the body) to generalized seizures (involving the entire body). Seizures occur due to abnormal electrical activity in the brain caused by the tumor or surrounding inflammation. They can be particularly distressing for patients and caregivers, often leading to falls, injuries, and increased anxiety. As the cancer progresses, seizures may become more frequent or difficult to control with medication.

Motor Skill Impairment

Terminal brain cancer can significantly affect movement and coordination as the tumor infiltrates or compresses areas of the brain responsible for motor function. Patients may experience weakness or paralysis on one side of the body, difficulty with fine motor skills, or problems with balance and walking. These impairments can manifest as unsteady gait, frequent falls, or inability to perform routine tasks like writing or buttoning clothes. The severity and specific nature of motor skill issues depend on the tumor location and size, potentially leading to a progressive loss of independence in daily activities.

Speech and Swallowing Difficulties

As terminal brain cancer progresses, patients often develop speech and swallowing problems. Speech difficulties can range from slurred speech to complete inability to communicate verbally, depending on the affected brain areas. Swallowing issues (dysphagia) are common, especially in end-stage brain cancer, making eating and drinking challenging and increasing the risk of aspiration. They significantly impact the patient’s ability to communicate, maintain nutrition, and engage in social interactions, often requiring alternative communication methods and feeding strategies.

Cognitive and Emotional Symptoms

Cognitive Decline

Cognitive decline is a hallmark symptom of terminal brain cancer, significantly impacting patients’ daily lives. Common cognitive symptoms include:

  1. Memory loss: Patients may struggle with short-term memory, forgetting recent events or conversations.
  2. Confusion: Disorientation about time, place, or personal information can occur.
  3. Difficulty concentrating: Focussing on tasks or maintaining conversations can become challenging.
  4. Impaired problem-solving: Complex thinking and decision-making abilities may deteriorate. 
  5. Language difficulties: Patients might struggle to find words or understand complex sentences. 

These symptoms can profoundly affect a patient’s ability to perform daily activities. Simple tasks like managing finances, following recipes, or remembering appointments become increasingly difficult. As the disease progresses, patients may lose the ability to live independently, requiring constant supervision and assistance. This cognitive impairment can be particularly distressing for both patients and their loved ones.

Emotional Changes

Terminal brain cancer frequently triggers significant emotional changes in patients. Common emotional symptoms include:

  • Depression: Feelings of hopelessness and sadness are common as patients grapple with their diagnosis.
  • Anxiety: Fear about the future and treatment outcomes can lead to persistent worry.
  • Mood swings: Rapid and unpredictable changes in emotional state may occur.
  • Irritability: Patients may become easily frustrated or angered.

Mental health support is crucial for both patients and families dealing with these emotional challenges. Professional counseling, support groups, and palliative care teams can provide valuable resources to help manage these symptoms and improve quality of life.

Behavioral Changes

Behavioral changes in terminal brain cancer patients can be dramatic and distressing. Examples include: 

  • Aggression: Patients may become uncharacteristically hostile or combative.
  • Personality shifts: Dramatic changes in temperament or core personality traits can occur.
  • Disinhibition: Loss of social filters leading to inappropriate behavior.
  • Apathy: Lack of interest in previously enjoyed activities or relationships.

These changes often result from tumor growth affecting areas of the brain responsible for personality and behavior regulation. Management strategies include medication to address specific symptoms, environmental modifications to reduce triggers, and education for caregivers on how to respond effectively to these changes. It’s crucial to remember that these behaviors are symptoms of the disease, not reflections of the patient’s true self.

Advanced Symptoms and Palliative Care

Loss of Consciousness

As terminal brain cancer progresses, patients often experience a gradual decline in consciousness. In a study of glioblastoma patients, 95 percent experienced a decrease in the level of consciousness in the last 10 days of life.

This decrease in consciousness is a significant indicator of disease progression, often signaling that the tumor is affecting areas of the brain responsible for arousal and awareness. It may be caused by intracranial pressure, tumor growth in specific brain regions, or complications from treatments. As consciousness declines, it becomes increasingly challenging to communicate with the patient, highlighting the importance of advance care planning and discussions about end-of-life wishes.

Palliative Care Approaches

Palliative care plays a crucial role in managing symptoms and providing comfort for terminal brain cancer patients. Its primary goal is to improve quality of life by addressing physical, emotional, and spiritual needs

Key aspects of palliative care include:

  1. Pain management: Tailored medication regimens to control pain, often including opioids and adjuvant therapies.
  2. Symptom control: Interventions to manage nausea, seizures, and other distressing symptoms.
  3. Emotional support: Counseling and therapy for patients and families to cope with anxiety, depression, and grief. 
  4. Spiritual care: Support from chaplains of spiritual advisors to address existential concerns.
  5. Family support: Education and resources for caregivers to manage patient care and their own well-being.
  6. Advance care planning: Assistance in making decisions about future care and end-of-life preferences.

Facilitating moves to hospice care: This can reduce the burden on caregivers and the family if treatment stops working or if the cancer worsens.

Palliative intervention might include using a combination of drugs to control pain, seizures, and other symptoms; incorporating massage, music therapy, or aromatherapy for relaxation and comfort; providing tools to help patients communicate as verbal abilities decline; offering feeding assistance or alternative nutrition methods when swallowing becomes difficult; and providing cognitive behavioral therapy or mindfulness techniques to manage anxiety and depression. 

Palliative care teams work closely with patients, families, and other healthcare providers to ensure comprehensive, compassionate care throughout the course of the illness, focusing on maximizing comfort and quality of life.

Happy woman and her ill father holding hands while communicating with a doctor in hospital ward.

Summary: What are the Symptoms of Terminal Brain Cancer?

Terminal brain cancer presents a complex array of symptoms affecting physical, cognitive, and emotional well-being. From persistent headaches and seizures to cognitive decline and behavioral changes, these symptoms significantly impact patients’ quality of life. Recognizing and managing these symptoms is important to provide effective care and comfort to those affected. As the condition progresses, palliative care becomes increasingly important, focusing on pain management, symptom control, and emotional support for both patients and their families. If you or a loved one is facing terminal brain cancer, don’t hesitate to reach out to healthcare providers for both patients and their families. 

If you want to be proactive about your health, why not book an Ezra full-body MRI? Our annual scan catches potential cancer earlier, leveraging artificial intelligence through the screening process to make it more efficient, affordable, and faster.

Understand your risk for cancer with our 5 minute quiz.

Our scan is designed to detect potential cancer early.

References

1. Glioblastoma Multiforme. AANS. Accessed May 1, 2025. https://www.aans.org/patients/conditions-treatments/glioblastoma-multiforme/

2. Glioblastoma. Accessed May 1, 2025. https://www.cancerresearchuk.org/about-cancer/brain-tumours/types/glioblastoma

3. Glioblastoma Multiforme (GBM) | Treatment and Prognosis. Brain Tumour Research. Accessed May 1, 2025. https://braintumourresearch.org/pages/types-of-brain-tumours-glioblastoma-multiforme-gbm

4. Wen X, Shao Z, Chen X, et al. A multifunctional targeted nano-delivery system with radiosensitization and immune activation in glioblastoma. Radiat Oncol. 2024;19:119. doi:10.1186/s13014-024-02511-9

5. Christ SM, Thiel GW, Heesen P, et al. Influence of brain metastases on the classification, treatment, and outcome of patients with extracranial oligometastasis: a single-center cross-sectional analysis. Radiat Oncol. 2024;19:148. doi:10.1186/s13014-024-02542-2

6. Schroeder T, Bittrich P, Kuhne JF, et al. Mapping distribution of brain metastases: does the primary tumor matter? J Neurooncol. 2020;147(1):229-235. doi:10.1007/s11060-020-03419-6

7. Sumera, Anwer F, Waseem M, et al. Molecular Docking and Molecular Dynamics Studies Reveal Secretory Proteins as Novel Targets of Temozolomide in Glioblastoma Multiforme. Molecules. 2022;27(21):7198. doi:10.3390/molecules27217198

8. Park YW, Vollmuth P, Foltyn-Dumitru M, et al. The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 1—Key Points of the Fifth Edition and Summary of Imaging Findings on Adult-Type Diffuse Gliomas. Journal of Magnetic Resonance Imaging. 2023;58(3):677-689. doi:10.1002/jmri.28743

9. Zumel-Marne A, Kundi M, Castaño-Vinyals G, et al. Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study. J Neurooncol. 2020;147(2):427-440. doi:10.1007/s11060-020-03437-4

10. What is brain cancer. The Brain Tumour Charity. Accessed May 1, 2025. https://www.thebraintumourcharity.org/brain-tumour-diagnosis-treatment/how-brain-tumours-are-diagnosed/brain-tumour-biology/brain-cancer/

11. Symptoms of End-Stage Brain Cancer. moffitt. Accessed May 1, 2025. https://www.moffitt.org/cancers/brain-cancer/faqs/what-are-the-symptoms-of-end-stage-brain-cancer/

12. Laribee RN, Boucher AB, Madireddy S, et al. The STAT3-Regulated Autophagy Pathway in Glioblastoma. Pharmaceuticals (Basel). 2023;16(5):671. doi:10.3390/ph16050671

13. Pace A, Di Lorenzo C, Guariglia L, et al. End of life issues in brain tumor patients. J Neurooncol. 2009;91(1):39-43. doi:10.1007/s11060-008-9670-x

14. Pfund Z, Szapáry L, Jászberényi O, et al. Headache in intracranial tumors. Cephalalgia. 1999;19(9):787-790; discussion 765. doi:10.1046/j.1468-2982.1999.1909787.x

15. Forsyth PA, Posner JB. Headaches in patients with brain tumors: a study of 111 patients. Neurology. 1993;43(9):1678-1683. doi:10.1212/wnl.43.9.1678

16. Signs and Symptoms of Adult Brain and Spinal Cord Tumors. Accessed May 1, 2025. https://www.cancer.org/cancer/types/brain-spinal-cord-tumors-adults/detection-diagnosis-staging/signs-and-symptoms.html

17. Personality changes and brain tumours. The Brain Tumour Charity. Accessed May 1, 2025. https://www.thebraintumourcharity.org/living-with-a-brain-tumour/side-effects/personality-changes/

18. Coping with brain tumours. Accessed May 1, 2025. https://www.cancerresearchuk.org/about-cancer/brain-tumours/living-with/coping

19. Chang SM, Dunbar E, Dzul-Church V, et al. End-of-Life Care for Brain Tumor Patients. ManualForHealthcareProviders. Accessed May 1, 2025. https://braintumorcenter.ucsf.edu/sites/default/files/Documents/ManualForHealthcareProviders.pdf

20. Sizoo EM, Braam L, Postma TJ, et al. Symptoms and problems in the end-of-life phase of high-grade glioma patients. Neuro Oncol. 2010;12(11):1162-1166. doi:10.1093/neuonc/nop045

21. Koekkoek JAF, Dirven L, Reijneveld JC, et al. Epilepsy in the end of life phase of brain tumor patients: a systematic review. Neurooncol Pract. 2014;1(3):134-140. doi:10.1093/nop/npu018

22. Saviuk M, Sleptsova E, Redkin T, et al. Unexplained Causes of Glioma-Associated Epilepsies: A Review of Theories and an Area for Research. Cancers (Basel). 2023;15(23):5539. doi:10.3390/cancers15235539

23. Singh G, Rees JH, Sander JW. Seizures and epilepsy in oncological practice: causes, course, mechanisms and treatment. J Neurol Neurosurg Psychiatry. 2007;78(4):342-349. doi:10.1136/jnnp.2006.106211

24. Gerstenecker A, Nabors LB, Meneses K, et al. Cognition in patients with newly diagnosed brain metastasis: profiles and implications. J Neurooncol. 2014;120(1):179-185. doi:10.1007/s11060-014-1543-x

25. Fang D, Jiang J, Sun X, et al. Attention dysfunction of postoperative patients with glioma. World J Surg Oncol. 2014;12:317. doi:10.1186/1477-7819-12-317

26. Hendrix P, Hans E, Griessenauer CJ, et al. Neurocognitive status in patients with newly-diagnosed brain tumors in good neurological condition: The impact of tumor type, volume, and location. Clin Neurol Neurosurg. 2017;156:55-62. doi:10.1016/j.clineuro.2017.03.009

27. Faulkner JW, Wilshire CE, Parker AJ, et al. An evaluation of language in brain tumor patients using a new cognitively motivated testing protocol. Neuropsychology. 2017;31(6):648-665. doi:10.1037/neu0000374

28. Boele FW, Rooney AG, Grant R, et al. Psychiatric symptoms in glioma patients: from diagnosis to management - PMC. Psychiatric symptoms in glioma patients: from diagnosis to management. 2015;11:1413-1420. doi:10.2147/NDT.S65874

29. Thier K, Calabek B, Tinchon A, et al. The Last 10 Days of Patients With Glioblastoma: Assessment of Clinical Signs and Symptoms as well as Treatment. Am J Hosp Palliat Care. 2016;33(10):985-988. doi:10.1177/1049909115609295

30. Schnurman Z, Mashiach E, Link KE, et al. Causes of Death in Patients With Brain Metastases. Neurosurgery. 2023;93(5):986-993. doi:10.1227/neu.0000000000002542

31. Christmas C, Rogus-Palia N. Swallowing disorders and aspiration in palliative care: Assessment and strategies for management. UpToDate. Accessed May 1, 2025. https://www.uptodate.com/contents/swallowing-disorders-and-aspiration-in-palliative-care-assessment-and-strategies-for-management/print

32. Rabab’h O, Al-Ramadan A, Shah J, et al. Twenty Years After Glioblastoma Multiforme Diagnosis: A Case of Long-Term Survival. Cureus. 13(6):e16061. doi:10.7759/cureus.16061

33. Mihelson N, McGavern DB. Viral Control of Glioblastoma. Viruses. 2021;13(7):1264. doi:10.3390/v13071264

34. cancer CCS/ S canadienne du. Survival statistics for brain and spinal cord tumours. Canadian Cancer Society. Accessed May 1, 2025. https://cancer.ca/en/cancer-information/cancer-types/brain-and-spinal-cord/prognosis-and-survival/survival-statistics

35. About Glioblastoma. National Brain Tumor Society. Accessed May 1, 2025. https://braintumor.org/events/glioblastoma-awareness-day/about-glioblastoma/

36. Gul S. Stage 4 Brain Cancer Timeline: What You Need to Know %. Massive Bio. January 10, 2025. Accessed May 1, 2025. https://massivebio.com/stage-4-brain-cancer/

37. Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA. 2013;310(17):1842-1850. doi:10.1001/jama.2013.280319

38. Who Should Get Palliative Care and Why? Accessed May 1, 2025. https://www.cancer.org/cancer/managing-cancer/palliative-care/who-should-get-palliative-care.html

39. Wessex Palliative Care Physicians. The Palliative Care Handbook. A Good Practice Guide. 2019. Accessed May 1, 2025. https://www.ruh.nhs.uk/for_clinicians/departments_ruh/palliative_care/documents/palliative_care_handbook.pdf

40. What happens at the end of life? The Brain Tumour Charity. Accessed May 1, 2025. https://www.thebraintumourcharity.org/living-with-a-brain-tumour/end-of-life-bereavement/what-happens-end-life/