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The Ezra Full-body MRI covers all the cancers listed below. Click any of the cancers to see clinical research comparing an Ezra MRI with other screening modalities.
New onset or pattern change of headaches, unexplained nausea and vomiting, vision or hearing problems, difficulty balancing or walking, speech problems, personality or behavior changes, seizures.
MRI with AI Assisted Image Analysis: AI was used to assist radiologists in segmenting the brain into normal and abnormal tissue.1https://www.hindawi.com/journals/ijbi/2017/9749108/
MRI for Brain Tumor Characterization: MRI was successfully used to differentiate high-grade and low-grade gliomas, as well as metastasis.2https://www.tomography.org/volume-4/issue-1-march/research-articles/j-tom-2018-00020
MRI Contrast: There was found to be no significant difference in the detection of brain tumors between contrast and non-contrast enhanced MRI scans in a cohort of children with prior brain tumors.3https://journals.sagepub.com/doi/10.1177/1971400919845619
Swelling, pain, or a lump in the front of the neck, trouble swallowing, a constant cough that is not due to a cold, changes in your voice.
MRI: MRI is highly accurate in differentiating benign and malignant lesions on the basis of apparent diffusion coefficient values obtained from diffusion weighted images. 4http://www.ajnr.org/content/29/3/563
Diffusion weighted MRI: DW-MRI images were used to risk stratify cases of thyroid cancer.5https://www.liebertpub.com/doi/10.1089/thy.2014.0419
CT and MRI: CT and MRI were both found to be useful in assessing the extrathyroid extension of known cancer.6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613791
Coughing up blood, shortness of breath, chest pain, losing weight without trying.
CT and Chest X-Ray: This paper details the sensitivity and specificity of low-dose CT and chest X-Rays for lesion detection in a lung-cancer screening cohort.9https://www.ncbi.nlm.nih.gov/pubmed/18475292
Breast lump, change in the size/ shape/ appearance of a breast, redness/ pitting/ peeling/ scaling/ crusting/ flaking of the skin on the breast.
MRI for the Detection of Breast Cancer – Contrast enhanced and DW imaging had very high sensitivity and specificity values for the detection of malignant lesions.10https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014797/
Most people do not show symptoms from early stage liver cancer. Symptoms may include losing weight without trying, loss of appetite, upper abdominal pain, nausea and vomiting, yellow discoloration of the skin/ eyes, white chalky stool.
MRI vs. CT and US – MRI was shown to be the best imaging modality for the detection of lesions in a high-risk population cohort when compared to CT or ultrasound.12https://pubs.rsna.org/doi/10.1148/radiol.11110157
Diagnostic Performance of MRI – MRI has a higher sensitivity and similar specificity for the detection of liver lesions when compared to CT and US.13https://www.sciencedirect.com/science/article/pii/S1542356510009456?via%3Dihub
Signs and symptoms rarely present in the early stages of disease. In the later stages, kidney cancer may cause blood in urine, pain in the back/ side that doesn’t go away, loss of appetite, or unexplained weight loss.
MRI vs. CT – MRI showed similar sensitivity for the detection and staging of kidney cancer lesions as CT, and showed better specificity in both areas.14https://www.clinical-genitourinary-cancer.com/article/S1558-7673(18)30338-0/fulltext
Non-Contrast MRI – Diffusion-weighted MRI can be used to effectively characterize renal lesions.15https://pubs.rsna.org/doi/10.1148/radiol.2512080880
Signs and symptoms often don’t occur until the disease is advanced. They may include pain in the upper abdomen that radiates to your back, loss of appetite, unexplained weight loss, new-onset diabetes, yellowing of skin or eyes.
MRI vs. Other Imaging Modalities – In a large-population, mixed-patient cohort, MRI performed identically or better than CT, PET, or ultrasound for the detection pancreatic cancer.16https://www.sciencedirect.com/science/article/pii/S0720048X17301535?via%3Dihub
Weight gain, muscle weakness, nausea, vomiting, back pain, fever, loss of appetite, pink or purple stretch marks on the skin, hormone changes that result in the development of opposite-gender secondary sex characteristics (women – excess facial hair, hair loss, men – enlarged breast tissue, shrinking testicles).
Trouble urinating, decreased force of the urine stream, blood in semen, bone pain, erectile dysfunction.
Non-Contrast Enhanced MRI – NCE MRI has a high negative predictive value in ruling out clinically significant prostate cancer.19https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2683950
MRI to Avoid Unnecessary Biopsies – Using an MRI to triage suspicious cases allows nearly 30% of patients avoid a prostate biopsy.20https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32401-1/fulltext
MRI Prostate Cancer Detection Rate – The detection rate of clinically significant disease is higher with MRI than with standard “blind” biopsies.21https://synapse.koreamed.org/DOIx.php?id=10.3348/kjr.2017.18.4.597
Abdominal bloating or swelling, quickly feeling full when eating, unexplained weight loss, discomfort in the pelvis area, changes in bowel habits, frequent need to urinate.
Screening for Ovarian Cancer with CA-125 – This glycoprotein is used as a screening tool for ovarian cancer but has a high false positive rate and poor sensitivity and specificity values.22https://jcp.bmj.com/content/58/3/308.short
Diffusion weighted MRI – DW MRI had a high diagnostic ability for ovarian cancer detection.23https://insights.ovid.com/crossref?an=00005792-201705120-00006
MRI vs. CT – DW MRI performed better at diagnosing ovarian cancer and differentiating between benign and malignant lesions than CT.24https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723750/
Vaginal bleeding after menopause, bleeding between periods, abnormal/ watery/ blood-tinged discharge from your vagina, pelvic pain.
MRI vs. Other Imaging Modalities – MRI performs better than CT/PET-CT for evaluating local tumor extent in endometrial cancer.25https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769723/
Blood in urine, painful urination, pelvic pain.
Urine Cytology – This screening technique has a very low sensitivity for the detection of bladder cancer.27https://www.ncbi.nlm.nih.gov/pubmed?holding=jhumlib&otool=jhumlib&term=12559279
Diffusion Weighted MRI – DW MRI imaging demonstrates high sensitivity and specificity in the detection and staging of bladder tumors.28https://pubs.rsna.org/doi/10.1148/radiol.2511080873
Cytology and Cystoscopy – There is little evidence to demonstrate the efficacy of urine cystoscopy and cytology for bladder cancer screening.29https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.23395
|Used as a Screening Tool?|
Medium – Low